Pair Name	Vitamin C, GW841819X
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Gene Regulation	Down-regulation	Expression	HRH4	hsa59340
	Down-regulation	Expression	HAT1	hsa8520
	Down-regulation	Expression	BRD4	hsa23476
	Down-regulation	Expression	H4C12	hsa8362
In Vitro Model	A2058	Amelanotic melanoma	Homo sapiens (Human)	CVCL_1059
	SK-MEL-28	Cutaneous melanoma	Homo sapiens (Human)	CVCL_0526
	SK-MEL-2	Melanoma	Homo sapiens (Human)	CVCL_0069
	C8161	Cutaneous melanoma	Homo sapiens (Human)	CVCL_6813
	1205Lu	Cutaneous melanoma	Homo sapiens (Human)	CVCL_5239
In Vivo Model	Mice were then engrafted on the neck by injecting 2×10⁵ mouse melanoma cells, B16-F10, to produce experimental tumor.
Result	This study shows that ascorbate can enhance the efficacy of BET inhibitors, providing a possible clinical solution to challenges arising in phase I trials from the dose-dependent side effects of this class of epigenetic therapy.